Sustained Release

Sustained Release

Sustained-release preparations refer to preparations that can be continuously released for a long time to achieve long-acting effects after administration, and their drug release is mainly a first-order rate process. The controlled release preparations refer to the preparations that can automatically release the drug at a predetermined rate within a predetermined time, so that the blood drug concentration can be maintained within the effective concentration range for a long time, and the drug release is mainly within the predetermined time. Release at or near zero order rate.

Sustained and controlled release drugs are generally suitable for drugs with a short half-life, and their half-life is generally between 2 and 8 hours. The drugs made into sustained and controlled release preparations mainly include the following categories: anti-arrhythmic drugs, anti-angina, antihypertensive drugs, Antihistamines, bronchodilators, antiulcer drugs, antiasthma drugs, antipyretic analgesics, antipsychotics, iron salts, potassium salts, magnesium salts, etc.

The pharmaceutical release application, which is composed of water-soluble KimaCell Hypromellose HPMC with high viscosity and APIs, sustains the drug release by adjusting its dissolution rate. Sustained release of a drug offers an advantage of reducing dosing frequency, providing better patient acceptance and uniform drug effect. KimaCell Hypromellose HPMC controls drug release by forming hydrophilic matrix structure (like a gel) with water. KimaCell Hypromellose HPMC is one of widely used sustained releasing agent.

KimaCell Grade

Product Characteristic

Technical Data Sheet


Viscosity: Medium

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Viscosity: High

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