KimaCell® HPC-M Hydroxypropyl Cellulose is easy to bond into a group, and heating will further induce the viscosity of HPC. Drying with heat will aggravate the agglomeration, which can no longer be dispersed by sieving. Therefore, it is best to prevent moisture during the storage of HPC to prevent it from agglomerating.HPC is a highly viscous polymer. When detected by a mechanical sieve, particles with a small particle size will also adhere to the sieve and fail to pass through, resulting in unqualified test results. The standard method is to use a pneumatic sieve for particle size detection.
HPC, H-HPC, cellulose, 2-hydroxypropyl ether
KimaCell® HPC-M Hydroxypropyl cellulose mainly has two functions, the low-viscosity specification is used as a binder, and the high-viscosity specification is used as a hydrophilic gel sustained-release matrix tablet. As a binder, it has a solubilizing effect on the drug, which may be the effect of hydroxypropyl cellulose on inhibiting drug precipitation. Theoretically, the dissolution and precipitation of the drug are reverse reactions, and when the saturation concentration is reached, the equilibrium is reached, and the dissolution rate is equal to the precipitation rate. Hydroxypropyl cellulose has functional groups such as hydroxypropyl groups, which may interact with some drug groups and inhibit drug precipitation, thereby promoting the dissolution process to a certain extent, showing certain The solubilization effect is essentially the intermolecular interaction between the drug and the polymer.