KimaCell®HPMC F4M Hydroxypropyl methylcellulose is used as a binder and disintegrant. Low-viscosity HPMC dissolves in water to form a clear to milky white viscous colloidal solution, which can be directly used as a binder. HPMC can be used to improve the compressibility of drug particles.HPMC is a kind of non-ionic cellulose mixed ether. It is a semi-synthetic, inactive, viscoelastic polymer, often used as a lubricant in ophthalmology, or as an excipient in oral drugs.
HPMC F4M Hydroxypropyl Methyl Cellulose (HPMC) | |
Physical Analysis | |
Appearance | White to slightly off-white fibrous or granular powder. |
Identification A to E | Conform |
Solution appearance | Conform |
Methoxy | 27.0-30.0% |
Hydroxypropoxy | 4.0-7.5% |
Loss on drying | 5.0% Max |
Residue on ignition | 1.5% Max |
pH | 5.0-8.0 |
Apparent viscosity | 3200-4800cps |
Particle size | Min. 98% pass through 100 mesh |
Heavy Metals | |
Heavy Metal | ≤10ppm |
Arsenic | ≤3ppm |
Lead | ≤3ppm |
Mercury | ≤1ppm |
Cadmium | ≤1ppm |
Micro bacteria | |
Total plate count | ≤1000cfu/g |
Yeast and Mould | ≤100cfu/g |
Coli form | Absent/g |
Salmonella | Absent/g |
KimaCell® HPMC F4M is widely used in pharma industry.
Sustained-release agent: With 2-3 grams per day, the feeding amount of each 1-2G will show effect in 4-5 days.
Encapsulation: the encapsulation agent is made into an organic solvent solution or an aqueous solution for administration of tablets, especially for the prepared granules to be spray-encapsulated.
Eye drops: Since the osmotic pressure of methylcellulose aqueous solution is the same as that of tears, it is less irritating to the eyes, so it is added to eye drops as a lubricant for contacting the eyeball lens.
Jelly: as the base material of jelly-like external medicine or ointment.
Dipping medicine: as a thickener and water retention agent.