KimaCell®HPMC K100M is Nonionic cellulose ethers which are widely used in the pharmaceutical industry as pharmaceutical excipients, such as thickeners, dispersants, emulsifiers and film-forming agents. It is used for film coating and adhesive on tablet drugs, and also used for suspensions, ophthalmic preparations, sustained and controlled release matrix and floating tablets, etc. Due to the extremely strict requirements on the purity and viscosity of the product, the pharmaceutical grade cellulose ether has a relatively complicated production process and more washing procedures. Compared with other grades of cellulose ether products, the collection rate of finished products is low, the production cost is high, and the added value of the product is low.
HPMC K100M ( 9004 65 3 )
Hydroxypropyl Methyl Cellulose (HPMC)
White to slightly off-white fibrous or granular powder.
Identification A to E
Loss on drying
Residue on ignition
Min. 98% pass through 100 mesh
Total plate count
Yeast and Mould
KimaCell® HPMC K100M is used in Gel micelles prepared for drug delivery.
Micelles usually refer to amphiphilic block copolymers (one end is a hydrophilic polymer and the other end is a hydrophobic polymer) when a critical concentration is reached in a solution, which is formed by intermolecular hydrogen bonds, van der Waals forces, and hydrophobic interactions. A core-shell structure with spontaneously formed nanoscale hydrophilic outer shell and hydrophobic inner shell. This hollow structure can store drug molecules and can be used as a drug carrier. The co-solvent evaporation method (spray drying and rotary evaporation to dry the solvent) made the low-viscosity grade polymer HPMC into micelles for the efficient encapsulation of the low water-soluble drug simvastatin to improve the dissolution rate and bioavailability of the drug.