KimaCell®HPMC K4M hydroxypropyl methyl cellulose is a non-toxic, odorless, white or off-white substance with strong stability to heat, light, and humidity, which is made by etherification of alkali cellulose, propylene oxide, and alkyl chloride. Powder. In the pharmaceutical industry, it is mainly used as a rate-controlling polymer material for coating materials, film materials, and sustained-release preparations. It can also be used as a stabilizer, suspending agent, tablet binder, and viscosity enhancer.
HPMC K4M Hydroxypropyl Methyl Cellulose (HPMC) | |
Physical Analysis | |
Appearance | White to slightly off-white fibrous or granular powder. |
Identification A to E | Conform |
Solution appearance | Conform |
Methoxy | 19.0-24.0% |
Hydroxypropoxy | 4.0-12.0% |
Loss on drying | 5.0% Max |
Residue on ignition | 1.5% Max |
pH | 5.0-8.0 |
Apparent viscosity | 3200.0-4800.0cps |
Particle size | Min. 98% pass through 100 mesh |
Heavy Metals | |
Heavy Metal | ≤10ppm |
Arsenic | ≤3ppm |
Lead | ≤3ppm |
Mercury | ≤1ppm |
Cadmium | ≤1ppm |
Micro bacteria | |
Total plate count | ≤1000cfu/g |
Yeast and Mould | ≤100cfu/g |
Coli form | Absent/g |
Salmonella | Absent/g |
KimaCell® HPMC K4M is currently one of the largest pharmaceutical excipients at home and abroad. Because of its molecular weight and viscosity, HPMC can be used as: binder, disintegrant, slow and controlled release agent, coating film-forming agent, etc. agent etc.
The HPMC used as the adhesive is of low viscosity specification, and the HPMC solution with a concentration of 2-5% is commonly used as the adhesive, which can make the disintegration rapid and the stripping speed up. Different concentrations have different viscosities, which depends on the nature of the material to be selected through experiments!