KimaCell® L-HPC LH11 Low substituted Hydroxypropyl Cellulose is a multi-purpose non-ionic cellulose derivative. It is mainly used as a disintegrant and binder for solid preparations. Because its powder has a large surface area and porosity, so it can quickly absorb water and swell. When it is used in tablets, it will disintegrate the tablets quickly. At the same time, its rough structure has a large inlay between the drug and the particles, which can significantly improve the hardness of the tablet without affecting the hardness of the tablet. Disintegration, thereby accelerating the dissolution rate of the drug and improving the bioavailability. As a disintegrant, the dosage is generally about 2-5%. In the production of tablets, it can be used for internal addition in wet granulation, or it can be added externally or both internally and externally for better results. When used as a tablet binder, wet granulation is generally used in an amount of 2-20%.
Low-Substituted Hydroxypropyl Cellulose
L-HPC, cellulose, 2-hydroxypropyl ether
White or light gray mobile power with odorless and tasteless
LOSS ON DRYING
RESIDUE ON IGNITION
KimaCell® L-HPC LH11 Low-Substituted Hydroxypropyl Cellulose is widely used in wet granulation, L-HPC has a "buffering effect", which makes the process of making soft materials stable in a wide range of water content. This is also a typical application of LH-11. Especially for active ingredients with poor solubility and wettability, the disintegration can be improved by adding more amount of L-HPC. For this reason, the amount of L-HPC added in the tablet can be as high as 20-40%. Despite such a high dosage, unlike other ionic disintegrants, L-HPC does not suffer from stability problems. In this application, the tablet disintegrates into very small individual particles, so dissolution is complete very quickly.
L-HPC has a dual function as a disintegrant and binder. Therefore, it is not only suitable for high-speed shear granulation, but also for fluidized bed granulation. Fluidized bed granulation with L-HPC can produce high hardness, fast disintegrating tablets even for drugs with poor compressibility.