KimaCell®HPMC E15 Hydroxypropylmethylcellulose is a water-soluble cellulose polymer that helps optimize the solubility enhancement of poorly soluble drugs by maintaining a stable solid dispersion and inhibiting API crystallization.
More sophisticated drug discovery techniques have resulted in pipeline compounds requiring enhanced solubility to achieve therapeutic efficacy. Solid dispersion is one of the key technologies for formulating oral solid dosage forms containing APIs with bioavailability challenges. HPMC is specifically designed for the production of solid dispersions in the pharmaceutical industry by spray drying or hot melt extrusion.
Hydroxypropyl Methyl Cellulose (HPMC)
White to slightly off-white fibrous or granular powder.
Identification A to E
Loss on drying
Residue on ignition
Min. 98% pass through 100 mesh
Total plate count
Yeast and Mould
KimaCell® HPMC E15 is widely used in pharmaceutical excipients.
HPMC E15 can be used as a binder for wet granulation of tablets at 3-5% of the finished tablet weight. HPMC E15 produces stronger granules compared to granules made with HPMC E15, which means that disintegration and dissolution times may be affected as harder tablets are produced.
Thickener and suspending agent
HPMC E15 can be used as a viscosity modifier in many cream, ointment, suspension formulations, including ophthalmic formulations.
KimaCell E15 grade is used in systems where high transparency is required and ease of filtration is an important parameter.