KimaCell®HPMC E15 Hydroxypropylmethylcellulose is a water-soluble cellulose polymer that helps optimize the solubility enhancement of poorly soluble drugs by maintaining a stable solid dispersion and inhibiting API crystallization.
More sophisticated drug discovery techniques have resulted in pipeline compounds requiring enhanced solubility to achieve therapeutic efficacy. Solid dispersion is one of the key technologies for formulating oral solid dosage forms containing APIs with bioavailability challenges. HPMC E15 is specifically designed for the production of solid dispersions in the pharmaceutical industry by spray drying or hot melt extrusion.
White to slightly off-white fibrous or granular powder.
Identification A to E
Loss on drying
Residue on ignition
Min. 98% pass through 100 mesh
Total plate count
Yeast and Mould
HPMC 15 CPS means Hydroxypropyl Methylcellulose with a viscosity of 15 centipoises (cps). It is a type of cellulose-based polymer commonly used in various industries, including pharmaceuticals, cosmetics, and construction. The "15 cps" specification indicates the viscosity of the HPMC solution, with higher numbers indicating thicker solutions. This viscosity is important for controlling the flow and thickness of products in which HPMC E15 is used, such as in pharmaceutical tablets.
HPMC E15 refers to Hydroxypropyl Methyl Cellulose （9004 65 3）with a nominal viscosity of 12.0-18.0 centipoises (cPs). The viscosity of HPMC E15 can vary slightly depending on the concentration and temperature of the solution it is dissolved in. However, the nominal viscosity value of 12-18 mPa.s provides a general indication of its viscosity range.
Viscosity is a measure of a fluid's resistance to flow. In the case of HPMC E15, the higher viscosity indicates that it forms a more viscous solution compared to lower viscosity grades of HPMC. HPMC E15 viscosity makes it suitable for applications that require thicker and more stable formulations.
It's important to note that the viscosity of HPMC E15 can be further adjusted by varying the concentration of the HPMC powder in the solution. Higher concentrations of HPMC will generally result in higher viscosity solutions.
When using HPMC E15 in formulations, it is advisable to consult the manufacturer's technical data sheet or product specifications for precise information on viscosity and recommended usage levels. The technical data provided by the manufacturer of HPMC E 15 will offer detailed information on the viscosity range, methods of measurement, and guidelines for formulating with HPMC E15.
KimaCell® HPMC E15 is widely used in pharmaceutical excipients.
HPMC E15 can be used as a binder for wet granulation of tablets at 3-5% of the finished tablet weight. HPMC E15 produces stronger granules compared to granules made with HPMC E15, which means that disintegration and dissolution times may be affected as harder tablets are produced.
Thickener and suspending agent
HPMC E15 can be used as a viscosity modifier in many cream, ointment, suspension formulations, including ophthalmic formulations.
KimaCell E15 grade is used in systems where high transparency is required and ease of filtration is an important parameter.