KIMA CHEMICAL CO.,LTD.
KIMA CHEMICAL CO.,LTD.
HPMC E15

HPMC E15

KimaCell®HPMC E15 Hydroxypropylmethylcellulose is a water-soluble cellulose polymer that helps optimize the solubility enhancement of poorly soluble drugs by maintaining a stable solid dispersion and inhibiting API crystallization.

More sophisticated drug discovery techniques have resulted in pipeline compounds requiring enhanced solubility to achieve therapeutic efficacy. Solid dispersion is one of the key technologies for formulating oral solid dosage forms containing APIs with bioavailability challenges. HPMC is specifically designed for the production of solid dispersions in the pharmaceutical industry by spray drying or hot melt extrusion.


Where to buy Cas 9004-65-3
HPMC E15

Specification of HPMC E15


HPMC E15

Hydroxypropyl Methyl Cellulose (HPMC)

Physical Analysis

Appearance

White to slightly off-white fibrous or granular powder.

Identification A to E

Conform

Solution appearance

Conform

Methoxy

28.0-30.0%

Hydroxypropoxy

7.0-12.0%

Loss on drying

5.0% Max

Residue on ignition

1.5% Max

pH

5.0-8.0

Apparent viscosity

12-18cps

Particle size

Min. 98% pass through 100 mesh

Heavy Metals

Heavy Metal

≤10ppm

Arsenic

≤3ppm

Lead

≤3ppm

Mercury

≤1ppm

Cadmium

≤1ppm

Micro bacteria

Total plate count

≤1000cfu/g

Yeast and Mould

≤100cfu/g

Coli form

Absent/g

Salmonella

Absent/g


Application of HPMC E15


KimaCell® HPMC E15 is widely used in pharmaceutical excipients.

  • Tablet adhesive

    HPMC E15 can be used as a binder for wet granulation of tablets at 3-5% of the finished tablet weight. HPMC E15 produces stronger granules compared to granules made with HPMC E15, which means that disintegration and dissolution times may be affected as harder tablets are produced.

  • Thickener and suspending agent

    HPMC E15 can be used as a viscosity modifier in many cream, ointment, suspension formulations, including ophthalmic formulations.

    KimaCell E15 grade is used in systems where high transparency is required and ease of filtration is an important parameter.


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