KimaCell®HPMC E3 is pharmaceutical excipient grade hydroxypropyl methyl cellulose, hypromellose, is a cellulose-based polymer for film coating, pellet granulation, and hard capsule manufacturing. Hydroxypropylmethylcellulose (HPMC) is a semi-synthetic, inert, viscoelastic polymer used as eye drops, and as a tablet coating, binder, and controlled release ingredient in oral medicines, present in many of commercial products.
Hydroxypropyl Methyl Cellulose (HPMC)
White to slightly off-white fibrous or granular powder.
Identification A to E
Loss on drying
Residue on ignition
Min. 98% pass through 100 mesh
Total plate count
Yeast and Mould
KimaCell® HPMC E3 has become one of the most widely used pharmaceutical excipients at home and abroad, because HPMC has advantages that other excipients do not have.
Soluble in cold water below 40°C or 70% ethanol, basically insoluble in hot water above 60°C, but can gel.
HPMC is a kind of non-ionic cellulose ether. Its solution has no ionic charge and does not interact with metal salts or ionic organic compounds. Therefore, other excipients do not react with it during the preparation process.
It is relatively stable to acid and alkali, and can be stored for a long time between pH 3 and 11 without obvious change in viscosity. The aqueous solution of HPMC has anti-mildew effect and can maintain good viscosity stability during long-term storage. The quality stability of medicines using HPMC as preparation excipients is better than that of medicines using traditional excipients (such as dextrin, starch, etc.).
Different viscosity derivatives of HPMC can be mixed according to different ratios, and its viscosity can change according to certain rules, and has a good linear relationship, so it can be selected according to the demand. 2.5 Metabolism inert HPMC is not absorbed or metabolized in the body, and does not provide heat, so it is a safe pharmaceutical preparation excipient.
HPMC is generally considered a non-toxic and non-irritating material.