KIMA CHEMICAL CO.,LTD.
KIMA CHEMICAL CO.,LTD.
HPMC E3

HPMC E3

KimaCell®HPMC E3 is pharmaceutical excipient grade hydroxypropyl methyl cellulose, hypromellose, is a cellulose-based polymer for film coating, pellet granulation, and hard capsule manufacturing. Hydroxypropylmethylcellulose (HPMC) is a semi-synthetic, inert, viscoelastic polymer used as eye drops, and as a tablet coating, binder, and controlled release ingredient in oral medicines, present in many of commercial products.



Where to buy Cas 9004-65-3
HPMC E3

Specification of HPMC E3


HPMC E3

Hydroxypropyl Methyl Cellulose (HPMC)

Physical Analysis

Appearance

White to slightly off-white fibrous or granular powder.

Identification A to E

Conform

Solution appearance

Conform

Methoxy

28.0-30.0%

Hydroxypropoxy

7.0-12.0%

Loss on drying

5.0% Max

Residue on ignition

1.5% Max

pH

5.0-8.0

Apparent viscosity

2.4-3.6cps

Particle size

Min. 98% pass through 100 mesh

Heavy Metals

Heavy Metal

≤10ppm

Arsenic

≤3ppm

Lead

≤3ppm

Mercury

≤1ppm

Cadmium

≤1ppm

Micro bacteria

Total plate count

≤1000cfu/g

Yeast and Mould

≤100cfu/g

Coli form

Absent/g

Salmonella

Absent/g


Application of HPMC E3


KimaCell® HPMC E3 has become one of the most widely used pharmaceutical excipients at home and abroad, because HPMC has advantages that other excipients do not have.

  • Water solubility

    Soluble in cold water below 40°C or 70% ethanol, basically insoluble in hot water above 60°C, but can gel.

  • Chemical inertness

    HPMC is a kind of non-ionic cellulose ether. Its solution has no ionic charge and does not interact with metal salts or ionic organic compounds. Therefore, other excipients do not react with it during the preparation process.

  • Stability

    It is relatively stable to acid and alkali, and can be stored for a long time between pH 3 and 11 without obvious change in viscosity. The aqueous solution of HPMC has anti-mildew effect and can maintain good viscosity stability during long-term storage. The quality stability of medicines using HPMC as preparation excipients is better than that of medicines using traditional excipients (such as dextrin, starch, etc.).

  • Adjustable viscosity

    Different viscosity derivatives of HPMC can be mixed according to different ratios, and its viscosity can change according to certain rules, and has a good linear relationship, so it can be selected according to the demand. 2.5 Metabolism inert HPMC is not absorbed or metabolized in the body, and does not provide heat, so it is a safe pharmaceutical preparation excipient.

  • Security

    HPMC is generally considered a non-toxic and non-irritating material.




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