KimaCell® HPMC-P HP55 Hypromellose phthalate can be used as enteric coating materials and sustained-release matrix materials for tablets and granules, enteric capsule binders and microcapsule matrices, implants, gradient release systems, taste-masking agents, microspheres, oral For the preparation of membranes, solid dispersions, etc., the release rate is related to the pH value. Enteric coating material Hydroxypropyl Methylcellulose phthalate, established HPMCP viscosity and group quantitative method, made a preliminary investigation on the physical and chemical properties and stability of HPMCP, studied HPMCP The properties of the free film, and indomethacin and pantoprazole sodium as model drugs, the coating study was carried out. HPMCP was synthesized with hypromellose (HPMC) as the main raw material.
Hydroxypropyl Methyl Cellulose Phthalate
Hypromellose Phthalate, HPMC-P
Starts @ 5.5
Viscosity in cps@20C
Nominal Phthalyl content
27.0% - 35.0%
Free Phthalic Acid
KimaCell® HPMC-P HP55 is mainly used in enteric coating.
HP-55 is a commonly used model for enteric coating.
Compared with HP55, HP-55S has higher solution viscosity due to its higher polymerization, and the coating film has higher mechanical strength and higher ability to resist gastric acid. These features can effectively reduce the amount of coating solution used, and at the same time, it can effectively prevent the coating film from breaking when it is applied to brittle tablets and granules.
HP-55 can be dissolved in a lower pH environment, so it can be used in pharmaceutical preparations intended to be released in the upper small intestine.