What is Microcrystalline Cellulose?

What is Microcrystalline Cellulose?

What is Microcrystalline Cellulose?

What is Microcrystalline Cellulose?

MCC (microcrystalline cellulose) is a purified partially depolymerized cellulose, white, odorless, tasteless, in the form of a crystalline powder composed of porous particles. MCC is widely used in pharmaceutical, cosmetic, food and other industries. Different particle sizes and moisture contents have different properties and applications.

Microcrystalline cellulose has been included in the United States Pharmacopoeia, European Pharmacopoeia, Japanese Pharmacopoeia, Chinese Pharmacopoeia

Generic Name: Microcrystalline Cellulose

Synonyms: Celex, Emcocel, intercrystalline cellulose, etc.

CAS 9004 34 6

Molecular formula: (C6H10O5)n, n≈220

Molecular weight: about 36000

English abbreviation: MCC


1. In the Pharmaceutical Industry

Commonly used as adsorbent, suspending agent, diluent and disintegrating agent. Cellulose MCC is widely used in pharmaceutical formulations, mainly as a diluent and binder for oral tablets and capsules. It can be granulated by wet method or directly compressed by dry method. It has some lubricating and disintegrating effects, so it is very useful in tablet preparation.

2. In the Food Industry

In the food industry, MCC microcrystalline cellulose can be used as an important base material for functional foods, and is an ideal health food additive.

1). Can maintain emulsification and foam stability.

2). Can maintain high temperature stability.

3). Can improve liquid stability.

4). It can be used as a nutritional supplement and thickener.

5). It has many other uses.

3. Cosmetics

As an ingredient, MCC powder is used in the manufacture of a wide variety of cosmetic, skin and care products, as well as detergents.

Microcrystalline cellulose can be obtained by controlled hydrolysis of α-cellulose with dilute mineral acid solution, and α-cellulose can be obtained from plant fibers containing cellulose pulp. After the hydrolyzed cellulose is filtered, purified, and spray-dried by water slurry, it can form dry porous particles with a wide particle size distribution.

This product is widely used in oral preparations and foods, and is a relatively non-toxic and non-irritating substance. It is not absorbed orally and has almost no potential toxicity. Use of large amounts may cause mild diarrhea. As an excipient for pharmaceutical formulations there are no difficulties.


This product is a hygroscopic stable substance. Large quantities should be stored in an airtight container in a cool dry place.


Microcrystalline cellulose is incompatible with strong oxidizing agents.


This product is listed in GRAS, allowed as a food additive in Europe, listed in the FDA "Inactive Ingredients Guide", and allowed to be used for non-injection.


This product is white or off-white powder; odorless and tasteless.

This product is insoluble in ethanol, water, acetone or toluene.


Pharmaceutical Excipients, Fillers and Disintegrants

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